Biotech Publications

March 22, 2016
TEXAS Biotech Publications

Farra, Robert, et al. "First-in-human assessment of a without any cables controlled drug distribution microchip." Science Translational drug 4.122 (2012): 122ra21-122ra21.
This first-in-human medical test evaluated the pharmacokinetic pages of person parathyroid hormones (hPTH(1–34))delivered because of the microchip-based implant versus subcutaneous shots. Outcomes indicated that the release profile of hPTH(1–34) from microchip-based implant was comparable and bioequivalent into the profile of subcutaneous treatments. Furthermore, patients reported definitely whenever surveyed about their implant knowledge.

Prescott, James H., et al. "Chronic, programmed polypeptide distribution from an implanted, multireservoir microchip unit." Nature biotechnology 24.4 (2006): 437-438.
This first-in-animal study examined the capability of the microchip-based implant to supply leuprolide (an analog of a luteinizing hormone-releasing hormones which marketed for the treatment of prostate disease and endometriosis) over a 6-month period in puppies. Results supported the feasibility of using microchip-based implant technology to provide other healing peptides and proteins. Furthermore, the analysis proposed that medication distribution from a range of discrete reservoirs isn't restricted to solution-phase drug formulations, hence stability-optimized, solid-phase medicine formulations could be packaged and introduced in vivo.

Grayson, Amy C. Richards, et al. "Multi-pulse medicine delivery from a resorbable polymeric microchip unit." Nature products 2.11 (2003): 767-772.
The Microchips Biotech IP profile includes both electronically-controlled reservoir implants along with preprogrammed, non-electronic reservoir-based implants, made of resorbable polymers. This research evaluated the functionality of a biodegradable microchip implant and demonstrated that timed, pulsatile distribution is possible by different the molecular mass associated with membranes covering each reservoir.

Santini, John T., Michael J. Cima, and Robert Langer. "A controlled-release microchip." Nature 397.6717 (1999): 335-338.
MIT teachers Dr. Robert Langer and Dr. Michael Cima published link between the initial study demonstrating the power of a novel reservoir-based microchip implant to digitally launch solitary or multiple chemical substances, on need.

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