Nature Biotechnology submission

April 25, 2017
Submissions (as of

Beginning this month, Nature Biotechnology is recommending that raw data from proteomics and molecular-interaction experiments be deposited in a general public database before manuscript submitting.


Having less raw data sets of proteomics and molecular-interaction documents is a long-standing and pernicious problem. It not merely stymies the trade, contrast and reanalysis of experimental outcomes, additionally prevents the development of brand-new algorithms and data that may enhance the confidence in information and conclusions. Also, it undermines the capability of referees to totally measure the top-notch information promoting a manuscript's conclusions, often forcing them to evaluate results simply on 'good faith'. Comparison this with the situation in genome research and structural biology, where discover an abundance of community information units from DNA microarrays, genome sequencing and X-ray crystallography studies, and it's also not difficult to understand the reason why development in proteomics has lagged.

The main issue has been that high-throughput protein evaluation technologies like size spectrometry are nevertheless fairly younger, in addition to natural information output from devices just isn't represented in standard platforms. Additionally, necessary protein size spectrometrists have-been slow to distribute their information on larger community—a puzzling occurrence because of the large option of mass spectra for chemical substances and medications. But possibly the solitary most important roadblock was the chronic insufficient community repositories for proteomics and molecular-interaction information.

This has started to change, but utilizing the introduction of this International Molecular Exchange (IMEx) consortium and databases such as the European Bioinformatics Institute's PRIDE and IntAct, the Seattle-based Institute for Systems Biology's PeptideAtlas, the University of Michigan's Tranche and the Rockefeller/University of British Columbia's GPMDB. When it comes to moment we choose PRIDE and IMEx databases (IntAct, DIP, MINT) simply because they not merely are real databases with complex interfaces and accession figures, additionally provide a mechanism for referees to anonymously analysis submitted information sets.

Our objective in motivating data distribution to community repositories is always to enhance the energy, reproducibility and dissemination for the analysis posted within our pages. Its worth reiterating that publication of a paper includes an obligation on the part of writers to help make adequate data openly readily available for an experiment become reproduced. Public accessibility of results is also in line with the missions of investment companies.

Although our new plan on information deposition is a suggestion in the place of a requirement, we highly urge authors to comply for explanations enumerated above. We want to monitor the results for this initiative with a view to evaluating the long run feasibility of needing information deposition as an ailment of book.

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