Glycosides tablets

November 27, 2015
Molecules 20 08928 g005 1024

Cover imageA MSPD way for removal and clean-up of ginkgo elements.

UHPLC–QQQ-MS for simultaneous evaluation of 18 ginkgo components.

Direct quantification of 10 flavonol glycosides without hydrolysis.

Analysis of 12 Ginkgo biloba tablets for sale in the worldwide market.

Evaluation and quality control of Ginkgo biloba happen comprehensively examined. However, little attention has-been dedicated to the simultaneous removal and evaluation of flavonols and terpene trilactones, particularly for direct measurement of flavonol glycosides. This work described an immediate technique for one-step removal and measurement of the elements. A matrix solid stage dispersion (MSPD) strategy was made for the extraction of ginkgo ingredients and in contrast to the heat-reflux and ultrasonic removal techniques. An ultra-high performance fluid chromatography (UHPLC)–tandem-triple-quadrupole-mass spectrometry (QQQ-MS) strategy was developed for detection regarding the 18 elements, including 10 initial flavonol glycosides, 3 aglycones, and 5 lactones. Afterwards, the recommended method ended up being used for the evaluation of 12 G. biloba tablets. Results indicated that MSPD produced similar extraction performance but consumed less time and needed reduced solvent amounts weighed against main-stream methods.picture for unlabelled figure Without hydrolysis, the focus detected ended up being a lot nearer to the original within the test. The full total flavonol glycoside articles in ginkgo tablets ranged from 3.59 to 125.21 μg mg−1, together with terpene trilactone diverse from 3.45 to 57.8 μg mg−1 among different producers. Finally, the proposed MSPD and UHPLC–QQQ-MS is quick and sensitive and painful in offering extensive profile of substance constituents particularly the genuine flavonol glycosides for improved quality-control of ginkgo products.

Keywords

  • Ginkgo biloba;
  • Flavonol glycoside;
  • Terpene trilactone;
  • Matrix solid stage dispersion;
  • Triple quadrupole mass spectrometry
Source: www.sciencedirect.com
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