Pregnane glycosides

September 6, 2016
This plant has pregnane

Cover imageCaralluma sinaica is sold on neighborhood markets of Saudi Arabia for assorted health advantages but no phytochemical research has actually especially already been carried out about this species. NMR and UHPLC-ESI-TOF-MS profilings associated with ethanolic herb associated with entire plant unveil a tremendously complex phytochemical structure ruled by pregnanes. Detailed information on its constituents ended up being obtained after separation. Six pregnane glycosides had been acquired and characterized based on the extensive spectroscopic analysis (including IR, 1H NMR, 13C NMR and MS information), besides ten understood substances (seven pregnanes and three flavonoids). The compounds were identified as 12β-O-benzoyl-20-O-acetyl boucerin-3-O-6-deoxy-3-O-methyl-β-d-glucopyranosyl-(1→4)-β-d-cymaropyranosyl-(1→4)-β-d-cymaropyranoside, 12β-O-tigloyl-20-O-acetyl boucerin-3-O-β-d-glucopyranosyl-(1→4)-β-d-cymaropyranoside, 12β-O-benzoyl-20-O-acetyl boucerin-3-O-β-d-glucopyranosyl-(1→4)-β-d-digitalopyranosyl-(1→4)-β-d-cymaropyranosyl-(1→4)-β-d-cymaropyranoside, 12β-O-benzoyl-20-O-acetyl boucerin-3-O-β-d-glucopyranosyl-(1→4)-thevetopyranosyl-(1→4)-β-d-cymaropyranosyl-(1→4)-β-d-cymaropyranoside, 12β-O-benzoyl-20-O-tigloyl boucerin-3-O-β-d-glucopyranosyl-(1→4)-β-d-cymaropyranoside, 12β-20-O-dibenzoyl boucerin-3-O-β-d-glucopyranosyl-(1→4)-β-d-cymaropyranosyl-(1→4)-β-d-cymaropyranoside. Finally, the separated compounds were evaluated for his or her quinone reductase induction.

Graphical abstract

After profiling regarding the extract from Caralluma sinaica, 13 pregnane glycosides (six formerly unreported) with three flavonoids had been identified and considered for his or her quinone reductase induction.

Highlights

► NMR and UHPLC-TOF profiling of Caralluma sinaica expose its complex pregnane structure. ► Six and seven understood pregnanes were separated from C. sinaica. ► A quinone reductase induction task was shown for some pregnane glycosides. ► No relevant cytotoxicity had been uncovered when it comes to C. sinaica extract.

Keywords

  • Caralluma sinaica;
  • Asclepiadaceae;
  • Pregnane glycosides;
  • Quinone reductase induction
Source: www.sciencedirect.com
RELATED VIDEO
Human Nature in an Age of Biotechnology The Case for
Human Nature in an Age of Biotechnology The Case for ...
Plandai Biotechnology (PLPL) - Getting the Most Out of Nature
Plandai Biotechnology (PLPL) - Getting the Most Out of Nature
PDF Download Human Nature in an Age of Biotechnology The
PDF Download Human Nature in an Age of Biotechnology The ...
RELATED FACTS
Share this Post
latest post
Tweets