Quercetin glycosides

February 10, 2018
Of Quercetin Glycosides
  • Gotten Summer 3, 1996.
  • Revision obtained August 7, 1996.
  • Accepted August 13, 1996.

Abstract

It's also been shown by Hollman et al. (Am. J. Clin. Nutr., 62, 1276–1282) that flavonoid glycosides are preferentially consumed from dietary onions when compared to flavonoid aglycone. In the light of the, we compared the bioactivities regarding the two many abundant flavonoid glycosides we have purified from onions (quercetin-3, 4'-diglucoside and quercetin-4'-glucoside) to your quercetin aglycone, and to the greater generally studied commercially-available flavonoid glycosides, rutin (quercetin-3-rutinoside) and isoquercitrin (quercetin-3-glucoside). Quercetin aglycone was the best inducer of anticarcinogenic period II marker enzyme, quinone reductase (QR), in mouse Hepalclc7 cells. Of this glycosides, just quercetin-4'-glucoside could induce QR task within assay. Inhibition of NADPH/iron- and ascorbate/iron-induced lipid peroxidation of peoples liver microsomes, and Trolox C-equivalent antioxidant ability (TEAC), had been in addition measured. The 4'-glycosylation dramatically decreased task into the ‘antioxidant’ assays, whereas 3-substitutions produced much smaller changes. These outcomes show that the preferentially-absorbed quercetin glycosides in onions have markedly various biological properties compared to the aglycone.

Source: carcin.oxfordjournals.org
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